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目的:研究YWHAE基因多态性与中国汉族人群帕金森病之间的相关性。方法:采用TaqMan检测法对中国汉族人群258例帕金森病患者和260名正常对照YWHAE的3个位点(rs34041110,rs3752826,rs2131431)进行关联分析T,并使用SHEsis软件进行单核苷酸多态性分析,比较病例组和对照组等位基因频率,基因型频率及单倍型的差异。结果:我们发现YWHAE的三个位点基因频率,基因型频率两组间差异不明显(P>0.05)。rs34041110与rs3752826的LD分析其D’值r2均较大(D’=0.978,r2=0.875)。但进一步对两位点的单倍型分析发现其各种组合均无统计学差异。结论:本研究结果提示YWHAE基因的三个位点与中国汉族人群帕金森病的发生不存在相关性。
Objective: To study the association between YWHAE gene polymorphism and Parkinson’s disease in Chinese Han population. Methods: The TaqMan test was used to correlate T (258 locus of Parkinson’s disease patients) with 260 normal control YWHAE loci (rs34041110, rs3752826, rs2131431) in Chinese Han population. Single nucleotide polymorphisms Sex analysis, comparison of case group and control group allele frequency, genotype frequency and haplotype differences. Results: We found that there was no significant difference between the two genotypes of YWHAE (P> 0.05). The LD values of rs34041110 and rs3752826 were both larger (D ’= 0.978, r2 = 0.875). However, further analysis of haplotypes at the two loci showed no significant difference among the various combinations. Conclusion: The results of this study suggest that there is no correlation between the three sites of YWHAE gene and the occurrence of Parkinson’s disease in Chinese Han population.