论文部分内容阅读
单核苷酸多态性(single nucleotide olymorphisms,SNPs)是指在基因组水平上由单个核苷酸的变异所引起的DNA序列多态性,作为第三代遗传标志,SNPs检测对疾病相关基因的生物学基础性研究,针对个体的用药设计和治疗以及有关人类进化和演化的人类学研究都有重要意义。SNPs检测方法多种多样,该文对2型糖尿病相关的SNPs基因多态性检测方法进行了介绍,按照检测的基本原理划分为酶学方法和物理方法,并对相关的应用做了较详细的回顾和分析。
Single nucleotide polymorphisms (SNPs) are DNA sequence polymorphisms caused by a single nucleotide variation at the genome level. As the third generation of genetic markers, SNPs are used to detect disease-related genes Basic research in biology, drug design and treatment for individuals, and anthropological research on the evolution and evolution of humans are all important. SNPs detection methods are diverse, this article describes the detection of type 2 diabetes-related SNPs gene polymorphisms introduced in accordance with the basic principles of detection is divided into enzymatic methods and physical methods, and related applications made in more detail Review and analyze.