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目的探讨阵发性心房颤动(房颤)射频消融术后应用胺碘酮对复发率的影响。方法 48例阵发性房颤行射频消融术患者,均术前常规停用抗心律失常药物,术中采用环肺静脉隔离方法 ,术后随机分为胺碘酮组与非抗心律失常药物组,各24例。胺碘酮组口服胺碘酮3个月,其他治疗同非抗心律失常药物组。观察两组的复发情况。结果胺碘酮组复发率:首次治疗1周时为20.8%(5/24),1个月时为12.5%(3/24),3个月时为12.5%(3/24),12个月时为8.3%(2/24)。非抗心律失常药物组复发率:首次治疗1周时为50.0%(12/24),1个月时为37.5%(9/24),3个月时为37.5%(9/24),12个月时为8.3%(2/24)。两组首次治疗1周及治疗1、3个月时复发率比较差异具有统计学意义(P<0.05),治疗12个月时组间复发率比较差异无统计学意义(P>0.05)。结论阵发性房颤射频消融术后应用胺碘酮治疗可影响对3个月内复发率的判断,对12个月时的复发率无影响。
Objective To investigate the effect of amiodarone on recurrence after paroxysmal atrial fibrillation (AF) radiofrequency ablation. Methods Forty-eight patients with paroxysmal atrial fibrillation undergoing radiofrequency catheter ablation were routinely given anti-arrhythmic drugs before surgery. Circumferential pulmonary venous isolation was performed during the operation. Patients were randomly divided into amiodarone group and non-anti-arrhythmic drug group, Each 24 cases. Amiodarone group oral amiodarone 3 months, other treatment with non-anti-arrhythmic drug group. The recurrence of the two groups was observed. Results The relapse rate of amiodarone group was 20.8% (5/24) at the first treatment, 12.5% (3/24) at 1 month, 12.5% (3/24) at 3 months and 12 8.3% (2/24) at month. The relapse rates in non-antiarrhythmic drug group were 50.0% (12/24) at 1 week of first treatment, 37.5% (9/24) at 1 month, 37.5% (9/24) at 3 months, 12 8.3% (2/24) in months. The recurrence rates of the two groups for the first time of treatment and for the first and third month of treatment were statistically significant (P <0.05). There was no significant difference in recurrence rate between the two groups (P> 0.05) at 12 months. Conclusions The use of amiodarone after radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation can influence the judgment of the recurrence rate within 3 months and has no effect on the recurrence rate at 12 months.