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石棉是一种具有纤维状结构的硅酸盐,吸入后,不仅可引起石棉肺,而且能诱发间皮瘤、肺癌、肠癌等多种癌瘤。石棉的用途已多达3000种以上,危害十分广泛,国外如瑞典、丹麦等国家禁止使用蓝石棉,英、法等国对石棉的生产使用作了多种规定和限制。许多流行病学调查进一步证实石棉致癌,但仍存在一些问题,如不同种类和不同产地石棉的致癌性和强度是否有差别,其它纤维状物质是否也能致癌等,因此需要通过动物实验作进一步研究。 在石棉致纤维化问题上,Wagngr等(1963,1974)Wight和Kuschner报道了不同种类石棉可引起豚鼠和大鼠的肺部纤维化,长纤维的更为严重,国内也有报道。自70年代以来,许多研究的重点放在石棉致恶性肿瘤上,结果
Asbestos is a fibrous structure of silicate, inhalation, not only can cause asbestosis lung, but also induced mesothelioma, lung cancer, colon cancer and other cancer. The use of asbestos has up to more than 3,000 kinds, the harm is very wide, foreign countries such as Sweden, Denmark prohibit the use of blue asbestos, Britain, France and other countries on the production and use of asbestos made a variety of provisions and restrictions. Many epidemiological investigations have further confirmed the carcinogenicity of asbestos. However, there are still some problems such as whether the carcinogenicity and strength of asbestos from different species and areas differ from each other and whether other fibrous substances can cause cancer. Therefore, further studies in animal experiments are needed . Asbestos fibrosis, Wagngr et al (1963, 1974) Wight and Kuschner reported that different types of asbestos can cause lung fibrosis in guinea pigs and rats, more serious long fibers, has also been reported in China. Since the 1970s, much of the research has focused on asbestos-causing malignancies, as a result