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本文报道了正常妊娠和妊高征孕妇血清和羊水碱性核糖核酸酶（ＲＮａｓｅ）活性，总蛋白、白蛋白和尿酸含量的测定结果。描述了正常妊娠孕妇羊水碱性ＲＮａｓｅ活性的变化规律，即随着妊娠的进展，其碱性ＲＮａｓｅ活性逐渐下降，３６周时最低（７６７Ｕ／Ｌ），此后逐渐回升。同时测定结果显示妊高征孕妇血清碱性ＲＮａｓｅ活性（１１０９Ｕ／Ｌ）和尿酸含量（６１５．７６５μｍｏｌ／Ｌ）较正常组显著升高，总蛋白含量显著下降（６８．９７ｇ／Ｌ）。表明妊高征孕妇肾脏的滤过与排泄功能下降，其中碱性ＲＮａｓｅ活性的变化对早期发现肾贬滤过功能的损害有一定意义。因而认为该指标有可能是一个早期诊断妊高征的指标。
This article reports the results of determination of RNase activity, total protein, albumin and uric acid in serum and amniotic fluid of pregnant women and patients with PIH. The changes of RNase activity in amniotic fluid of normal pregnant women were described. The basic RNase activity decreased gradually with the progress of pregnancy, the lowest (767U / L) at 36 weeks and then gradually rose. The results also showed that serum alkaline RNase activity (1109U / L) and uric acid content (615.765μmol / L) in pregnant women with PIH were significantly higher than those in normal pregnant women, and the total protein content was significantly decreased (68.97g / L). The results showed that the renal filtration and excretion function of pregnant women with PIH decreased, and the change of basic RNase activity had some significance to the early detection of the impairment of kidney dehumidification function. So that the index may be an early diagnosis of pregnancy-induced hypertension index.