麻疹病毒(MV)是一种普遍存在的人类致病因子。近年来,国外学者对于MV和感染宿主的相互作用进行许多探讨,这些工作对手认识MV致病作用和宿主抗病毒免疫,了解持续感染和慢病毒感染的机理,掌握病情和判断预后均有意义。一、MV感染对宿主的损伤作用 MV的主要靶组织是淋巴和上皮组织。作为免疫器官的淋巴组织,MV在其中增殖,对免疫产生复杂的影响。 (一)对免疫活性细胞的病理性破坏麻疹急性期淋巴细胞总数,T、B淋巴细胞及其亚类数,无T、B标记的裸细胞数明显降低 Measles virus (MV) is a ubiquitous human pathogenic factor. In recent years, many foreign scholars discussed the interaction between MV and host infection. These working partners know the pathogenic role of MV and host anti-viral immunity, understand the mechanism of persistent infection and lentivirus infection, master the condition and judge the prognosis. First, the role of MV infection damage to the host MV’s main target tissue is lymphoid and epithelial tissue. As lymphoid tissues of immune organs, MVs proliferate therein, with a complex impact on immunity. (A) Pathological damage to immunocompetent cells The total number of lymphocytes, T, B lymphocytes and their subclasses in the acute stage of measles were significantly lower than those without T and B