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目的:探讨在10号染色体上磷酸酶和张力蛋白同系化合物缺失(PTEN) 和粘着斑激酶(FAK)在膀胱移行细胞癌中表达的意义。方法:应用 SP免疫组织化学染色法检测 96 例膀胱移行细胞癌中 PTEN和 FAK的表达。结果:PTEN和 FAK表达的阳性率在 Ta~1 中分别为71.43%(30/42)和47.62%(20/42), T2~4 分别为37.04%(20/54)和85.19% (46/54) (P < 0.05), G1~2 分别为48.65% (36/74)和68.92% (51/74), G3~4 分别为63.64%(14/22) 和68.18%(15/22)(P>0.05),在初发肿瘤中分别为58.67%(44/75)和62.67%(47/75),复发肿瘤中分别为28.57%(6/21)和90.48%(19/21)(P<0.05)。PTEN阳性表达中 FAK 阳性表达52.00% (26/50), PTEN阴性表达中FAK阳性表达86.96%(40/46)(P<0.05)。结论:PTEN和FAK的阳性表达与膀胱移行细胞癌的分期有关,与分级无关,PTEN可下调 FAK的表达,在复发肿瘤中 PTEN表达下调,FAK表达则增高。
Objective: To investigate the significance of the expression of PTEN and FAK on bladder transitional cell carcinoma on chromosome 10. Methods: SP immunohistochemical staining was used to detect the expression of PTEN and FAK in 96 cases of bladder transitional cell carcinoma. Results: The positive rates of PTEN and FAK expression in Ta ~ 1 were 71.43% (30/42) and 47.62% (20/42), respectively. The positive rates of PTEN and FAK were 37.04% (20/54) and 85.19% (P <0.05), G1 ~ 2 were 48.65% (36/74) and 68.92% (51/74) respectively, G3 ~ 4 was 63.64% (14/22) and 68.18% (15/22) (P> 0.05). The incidence of primary tumors were 58.67% (44/75) and 62.67% (47/75), respectively. The recurrence rates were 28.57% (6/21) and 90.48% <0.05). FAK positive expression was 52.00% (26/50) in PTEN positive and 86.96% (40/46) positive in PTEN negative (P <0.05). CONCLUSION: The positive expression of PTEN and FAK is related to the stage of bladder transitional cell carcinoma. Regardless of the grade, PTEN can down-regulate the expression of FAK. In recurrent tumors, the expression of PTEN is down-regulated and FAK is up-regulated.