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目的:探讨分析曲美他嗪治疗陈旧性心肌梗死合并心力衰竭的临床效果。方法:选择我院收治的86例陈旧性心肌梗死合并心力衰竭患者,随机分为观察组和对照组两组,每组43例,对照组给予常规治疗,观察组在与对照组相同治疗的基础上给予曲美他嗪治疗,比较两组治疗后心功能(NYHA)分级、B型脑钠肽(BNP)、心脏功能改善情况、治疗效果、6个月再入院率和不良反应情况。结果 :经治疗后,观察组NYHA分期及BNP显著低于对照组(P<0.05);观察组LVEF、CO及CI明显高于对照组(P<0.05);观察组治疗有效率显著优于对照组(93.02%vs 72.09%,P<0.05);观察组再入院率显著低于对照组(6.98%vs 27.91%,P<0.05);两组治疗期间均未发生明显不良反应。结论:曲美他嗪治疗陈旧性心肌梗死合并心力衰竭明显改善患者的心功能,降低患者的再入院率。
Objective: To investigate the clinical effect of trimetazidine in the treatment of old myocardial infarction complicated with heart failure. Methods: A total of 86 elderly patients with myocardial infarction and heart failure admitted to our hospital were randomly divided into two groups: observation group and control group, 43 cases in each group. The control group was given routine treatment. The observation group was the same as the control group Were given trimetazidine treatment. NYHA class, BNP, cardiac function, treatment effect, 6-month rehospitalization rate and adverse reactions were compared between the two groups. Results: After treatment, the NYHA stage and BNP in the observation group were significantly lower than those in the control group (P <0.05). The LVEF, CO and CI in the observation group were significantly higher than those in the control group (P <0.05) (93.02% vs 72.09%, P <0.05). The readmission rate of the observation group was significantly lower than that of the control group (6.98% vs 27.91%, P <0.05). No significant adverse reactions occurred during the two groups. CONCLUSIONS: Trimetazidine treatment of patients with old myocardial infarction with heart failure significantly improves cardiac function and reduces the rate of hospital admission.