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为了调查山西省阳泉市等地区食管癌高发病率的原因并探讨家族中有食管癌史的对食管癌发病率的影响。我们以原卟啉作为癌瘤的分子标志物 ,建立了通过血清荧光的检测进行恶性肿瘤诊断的方法 ,开展了食管癌流行病学调查。采用双盲法对 10位已确诊为食管癌的患者及其 56户有血缘关系的亲属共 3 16人进行了血清荧光检测。查出 56例阳性 ,其中包括 10位食管癌患者 ,对其余 46人进行了胃镜检查 ,未发现癌症 ,待继续随访查证。在普查过程中我们观察到 ,阳性例出现在 40年— 70年龄段的占阳性例的 80 % ;阳性例出现在 15户人家 ,5口人之家出现 2例阳性的有 3户 ,10口人之家出现 3例阳性的有 1户 ,10位食管癌患者的家庭出现 2例阳性的有 3户 ,呈现出家系性。
In order to investigate the causes of the high incidence of esophageal cancer in Yangquan City, Shanxi Province, and to explore the influence of the history of esophageal cancer in the family on the incidence of esophageal cancer. Using protoporphyrin as a molecular marker of carcinomas, we established a method for the diagnosis of malignant tumors by detecting serum fluorescence and conducted an epidemiological investigation of esophageal cancer. A double-blind method was used to detect the serum fluorescence of 10 16 confirmed esophageal cancer patients and 56 relatives of 56 relatives. 56 cases were positive, including 10 esophageal cancer patients, the remaining 46 were gastroscopy, no cancer was found, to be followed up for verification. During the census, we observed that the positive cases occurred in 80% of the positive cases between 40 years and 70 years of age. The positive cases occurred in 15 households, and the positive cases in 3 and 5 households were 3 and 10 There were 3 positive cases in the human family, and there were 3 positive cases in 2 out of 10 esophageal cancer families, showing a pedigree.