以1,3-二甲氧基苯为原料,经Vilsmeier法使用DMF直接甲酰化来经济合成2,4-二甲氧基苯甲醛,获得IR、NMR定性合格的产品,经正交试验优化后无需提纯即可制得纯度98.64%、收率94.2%的目标产物,精制后纯度可达到99.6%。 Using 1,3-dimethoxybenzene as raw material, 2,4-dimethoxybenzaldehyde was synthesized by Vilsmeier method using DMF direct formylation to obtain IR and NMR qualified products, which were optimized by orthogonal test After purification without purification, the target product with the purity of 98.64% and the yield of 94.2% can be obtained, and the purity after purification can reach 99.6%.