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给小鼠i.p.阿托品5mg/kg可导致自主活动增加。将毒扁豆硷(0.5mg/kg,ip)、安定(10mg/kg,ip)和苯巴比妥(100mg/kg,ip)分别与阿托品合用,均使小鼠活动减少,表现拮抗阿托品的中枢兴奋作用。兔icv阿托品1mg/kg后呈现强烈兴奋现象,EEG爆发多棘波,行为发生阵发性抽搐,强直性痉挛,70％死亡。氟呱啶醇和酚妥拉明对阿托品中枢兴奋作用无影响。24小时前icv密胆碱100mg/kg或同时用东莨菪碱(3mg/kg,icv)均能减弱阿托品的中枢兴奋作用,而毒扁豆碱(0.3mg/kg,iv)则对之影响不明显。安定(2mg/kg,iv)和苯巴比妥钠(60mg/kg iv)则有良好的拮抗阿托品中枢兴奋作用。上述结果提示阿托品中枢兴奋作用可能与阻断中枢抑制性M胆碱受体和促使Ach释放增加有关。
Mice given i.p. atropine at 5 mg / kg resulted in increased autonomic activity. Combining physostigmine (0.5 mg / kg, ip), diazepam (10 mg / kg, ip) and phenobarbital (100 mg / kg, ip) with atropine respectively reduced the activity of mice and showed antagonism to atropine Excitement. Rabbit icv atropine 1mg / kg showed a strong excitement phenomenon, EEG burst more spikes, the occurrence of paroxysmal convulsions, tonic spasms, 70% of deaths. Fluorpridol and phentolamine have no effect on atropine center excitability. Icv choline 100 mg / kg 24 hours ago or both scopolamine (3mg / kg, icv) can reduce the central stimulant effect of atropine, while the physostigmine (0.3mg / kg, iv) is not obvious. Diazepam (2mg / kg, iv) and phenobarbital sodium (60mg / kg iv) have a good antagonism of atropine central excitatory effects. The above results suggest that atropine central excitatory effect may be related to block the central inhibitory M cholinergic receptor and promote the release of Ach.