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采用L1210，SGC－7901细胞，观察鬼臼酰肼哌啶氮氧自由基腙（GP－1）及其还原物（GP－1－OH，GP－1-H）的体外抗肿瘤作用。结果表明三者均抑制L1210细胞增殖，IC50分别为1．57，4．02，13．68μmol／L：三者对SGC－7901细胞MTTformazan生成的抑制作用与细胞增殖试验相似，IC50分别为2.76，8.03，19．10μmol／L，GP-1作用最强。
L1210, SGC-7901 cells were used to observe the in vitro anti-tumor effects of podophylloyl piperidine nitroxide (GP-1) and its reductants (GP-1-OH, GP-1-H). The results showed that all three inhibited the proliferation of L1210 cells with IC50 of 1.57, 4.02, and 13.68 μmol/L, respectively: the inhibition of MTTformazan formation in SGC-7901 cells was similar to that in the cell proliferation assay, with an IC50 of 2.76. 8.03, 19.10 μmol/L, GP-1 had the strongest effect.