论文部分内容阅读
目的:探讨高危人乳头状瘤病毒(HPV)检测对薄层液基细胞学检测(TCT)结果异常者诊断的辅助作用。方法:对139例TCT检查结果异常的[其中未明确意义的不典型鳞状细胞(ASCUS)120例,低度鳞状上皮内病变(LSIL)17例,高度鳞状上皮内病变(HSIL)2例]患者进行HPV检测、阴道镜下宫颈活检。结果:①120例TCT提示ASCUS的患者中,HSIL 28例,检出率为23.3%;HSIL中高危HPV检出25例,检出率89.3%(25/28);低危HPV阳性及HPV阴性检出3例,检出率10.7%(3/28);高危HPV阳性者中HSIL检出25例,检出率为41%(25/61);低危HPV阳性及HPV阴性患者中HSIL为5%(3/59),并且均为CINⅡ期,统计学分析显示差异显著(P<0.05)。②17例TCT检测出的LSIL患者中,HSIL 9例,检出率为52.9%,均为高危HPV阳性者。③TCT检查HSIL患者2例,HPV高危型均阳性,病检提示均为宫颈鳞状细胞癌。结论:高危HPV检测能够对TCT结果异常患者进行确诊和鉴别,从而为后期的临床处理起到很好的指导作用。
Objective: To investigate the diagnostic value of high-risk human papillomavirus (HPV) test in diagnosis of abnormal liquid-based cytology (TCT). METHODS: One hundred and ninety-nine patients with abnormal TCT [including 120 cases of unspecified atypical squamous cell carcinoma (ASCUS), 17 cases of low grade squamous intraepithelial lesion (LSIL), and 2 cases of high grade squamous intraepithelial lesion (HSIL) 2 Cases] Patients with HPV testing, colposcopic cervical biopsy. Results: ①There were 28 cases of HSIL in 120 cases of HSUS detected by TCT, the detection rate was 23.3%; 25 cases of high-risk HPV were detected in HSIL, the detection rate was 89.3% (25/28); low-risk HPV positive and HPV negative Out of 3 cases, the detection rate was 10.7% (3/28). Among the high-risk HPV positive cases, 25 cases were detected by HSIL, the detection rate was 41% (25/61). The HSIL in low-risk HPV and HPV negative patients was 5 % (3/59), both of which were in CIN II stage. Statistical analysis showed significant difference (P <0.05). ② Among the 17 cases of LSIL detected by TCT, 9 cases of HSIL were found, the detection rate was 52.9%, all of them were high-risk HPV positive. ③ TCT examination HSIL patients in 2 cases, HPV high-risk type were positive, pathological examination showed cervical squamous cell carcinoma. Conclusion: High-risk HPV testing can diagnose and differentiate patients with abnormal TCT, which can guide the clinical treatment in the later period.