目的探讨碘-125粒子食管支架对晚期食管癌的治疗效果。方法19例晚期食管癌患者分为2组,A组12例应用普通食管支架治疗,B组7例应用带有碘-125粒子的放射性食管支架进行治疗。术中、术后观察随访支架置入成功率、生存期及并发症的发生率。结果A、B 2组支架置入成功率均为100.0%,吞咽困难记分均从3.3分改善到1分,B组的平均生存期为9.8个月,明显长于A组的4.8个月(P<0.01)。疼痛及移位并发症发生率分别为25.0%、28.6%,2组间无显著性差异(P>0.05)。结论碘-125粒子食管支架不但能明显改善吞咽困难症状,而且对癌肿进行组织间放疗,可明显延长患者生存期。 Objective To investigate the therapeutic effect of iodine-125 particle esophageal stent on advanced esophageal cancer. Methods Nineteen patients with advanced esophageal cancer were divided into two groups. Group A received routine esophageal stent in 12 cases and group B received radiation esophageal stent with iodine-125 particles in 7 cases. Intraoperative and postoperative follow-up stent placement success rate, survival and complication rates. Results The successful rates of stent implantation were 100.0% in group A and group B, respectively. The score of dysphagia improved from 3.3 to 1, and the average survival time in group B was 9.8 months, significantly longer than that in group A 4.8 months (P < 0.01). The incidence of pain and displacement complications were 25.0% and 28.6% respectively, with no significant difference between the two groups (P> 0.05). Conclusion Iodine-125 particle esophageal stent can not only significantly improve the symptoms of dysphagia, but also for inter-tumor radiotherapy of cancer can significantly prolong the survival of patients.