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昆明小鼠随机分成7组,1-5组小鼠皮下注射DMH,剂量20mg/kg体重,每周1次,连续20wk.第2-5组于注射前1wk开始灌胃儿茶素1mg、2mg、4mg、EGCG 2mg/每只/每日,第6组给几茶素3mg作为对照组,每周连续灌胃5次至23wk.第7组为溶剂对照组,27wk处死小鼠.结果显示:2组对照小鼠未发生肿瘤,DMH组大肠层发生率为80％,与第2-5组比较明显升高(P<0.0001),当同时用不同剂量儿茶素后,DMH诱发大肠癌的例数、瘤结数和肿瘤体积、累及肠周径
Kunming mice were randomly divided into 7 groups. 1-5 mice were subcutaneously injected with DMH at a dose of 20 mg/kg body weight once a week for 20 weeks. Groups 2-5 were given intragastric administration of catechins 1 mg, 2 mg at 1 week before injection. , 4mg, EGCG 2mg / each / daily, group 6 given 3mg of tea, as the control group, weekly gavage 5 times to 23wk. Group 7 as the solvent control group, 27wk killed the mice. The results show that: There were no tumors in the two groups of control mice. The occurrence rate of the large intestine layer in the DMH group was 80%, which was significantly higher than that in the group 2-5 (P<0.0001). DMH induced colorectal cancer when different doses of catechins were used simultaneously. Number of cases, number of nodules and tumor volume, peri-intestinal circumference involvement