为探讨 HP感染和细胞凋亡在胃粘膜病变中作用 ,用 TU NEl法检测了 136例胃粘膜病变患者的胃粘膜细胞凋亡情况。结果发现 :胃癌细胞凋亡减少 ;HP(+)者细胞凋亡较 HP(- )者明显增加 ,HP根除以后细胞凋亡有显著下降。这表明 HP可以诱导胃细胞凋亡 ,细胞凋亡受抑制可能是胃癌发病机制之一 ,根除 HP以减少细胞凋亡可能有助于预防胃粘膜病变的发生。 In order to investigate the role of HP infection and apoptosis in gastric mucosal lesions, TU NEl method was used to detect gastric mucosal cell apoptosis in 136 gastric mucosal lesions. The results showed that the apoptosis of gastric cancer cells was decreased; the apoptosis of HP (+) cells was significantly increased compared with that of HP (-), and the apoptosis was significantly decreased after HP eradication. This indicates that HP can induce apoptosis of gastric cells, inhibition of apoptosis may be one of the pathogenesis of gastric cancer. Eradication of HP to reduce apoptosis may help prevent gastric mucosal lesions.