论文部分内容阅读
目的 :对乳腺癌患者血清PRL及癌组织PRL R与预后因素的相关性进行比较研究。方法 :采用受体放射配基结合分析法及放射免疫分析法分别测定 94例乳腺癌患者细胞PRL R含量 (≥ 2 0fmol/mg蛋白为受体阳性 )和 75例患者血清PRL含量 (>2 5μg/L为激素阳性 )。统计分析两者与乳腺癌预后因素的相关性。结果 :PRL R阳性率与肿瘤大小、有无腋淋巴结转移、组织学分级、临床分期及增殖细胞核抗原 (PCNA)是否阳性有显著性相关 (P <0 .0 5) ;且PCNA弱阳性者较阴性者 ,淋巴结转移 1～ 3个者较无转移者PRL R阳性率均显著增高 (均P <0 0 5)血清PRL阳性率仅见与组织学级别及临床期别有显著性相关 (P <0 .0 5) ;且与PRL R在临床期别组中的阳性率比较 ,Ⅲ期患者PRL阳性率显著低于PRL R阳性率 ,乳腺癌PRL R与血清PRL阳性率间未见显著性相关 (P >0 .0 5)。结论 :PRL R或血清PRL阳性提示乳腺癌预后不良 ,PRL R估计预后较为灵敏、可靠。
Objective : To compare the correlation between serum PRL, PRL R and prognostic factors in breast cancer patients. METHODS: PRL R levels (≥ 20 fmol/mg protein as receptor positive) and serum PRL levels in 75 patients (94 g) were measured using receptor radioligand binding assay and radioimmunoassay, respectively. /L is hormone positive). Statistical analysis of the correlation between the two and breast cancer prognostic factors. Results: The positive rate of PRL R was positively correlated with tumor size, axillary lymph node metastasis, histological grade, clinical stage, and whether PCNA was positive (P < 0.05). The positive rate of PCNA was weaker. The positive rate of PRL R was significantly higher in all cases with negative lymph node metastases (1-3 cases) than those without metastasis (all P < 0.05). PRL positive rate was only associated with histological grade and clinical stage (P <0). .0 5) ; Compared with the PRL R positive rate in the clinical stage group, the positive rate of PRL in stage III patients was significantly lower than the positive rate of PRL R, and there was no significant correlation between the PRL ratio of breast cancer and the positive rate of serum PRL ( P >0 .0 5). Conclusion : The positive PRL R or serum PRL suggests poor prognosis of breast cancer. PRL R is more sensitive and reliable in estimating prognosis.