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在动物与临床研究中,有人发现毒扁豆碱能有效地对抗吗啡的呼吸抑制作用,而不影响吗啡的镇痛效果,但其作用的持续时间短。毒扁豆碱也能对抗抗胆碱能药、三环抗抑郁药和苯二氮类等药物过量引起的中毒。再者,毒扁豆碱治疗Alzheimer’s病的作用时间也短,需要频繁给药。本文作者为了延长毒扁豆碱的作用时间,将毒扁豆碱、水杨酸盐混合成一种控释、可注射的乳剂,以评价毒扁豆碱的体内释放。将精制磷脂和毒扁豆碱溶于油相,非离子乳化剂(聚氧化合物)和甘露醇溶于水相,两相分别加热至70℃。用磁力搅拌器进行分
In animal and clinical studies, it was found that physostigmine can effectively counteract the respiratory depression of morphine without affecting the analgesic effect of morphine, but its duration of action is short. Butyric acid also antagonizes anticholinergics, tricyclic antidepressants and benzodiazepines and other drugs caused by overdose. Furthermore, physostigmine treatment of Alzheimer’s disease is also a short duration of action, requiring frequent administration. In order to extend the action time of physostigmine, the authors mixed physostigmine and salicylate into a controlled-release and injectable emulsion to evaluate the in vivo release of physostigmine. The refined phospholipids and physostigmine are dissolved in the oil phase, the non-ionic emulsifier (polyoxygen compound) and mannitol are dissolved in the aqueous phase and the two phases are respectively heated to 70 ° C. Divide by a magnetic stirrer