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国内临床上常用的胰岛素制剂均制成注射剂。近年来,国外对胰岛素新剂型的研究报道较多,此外对胰岛素原料来源的研究亦有一些进展,介绍如下。1.口腔粘膜吸收制剂口腔牯膜吸收的胰岛素制剂包括口含片、舌下片、吹入散等。例如口含片的制法:取明胶2.5g 加水适量膨胀后,加柠檬黄(色素)0.3g、山梨醇0.25g 与胰岛素溶液(4000单位)50ml 充分混匀,混合物过筛,真空低温干燥、再加片剂辅料硬脂酸镁2g、滑石粉3g、Aerosil 0.07g共压制1000片。2.滴鼻用溶液西德与日本专利介绍鼻用胰岛素溶液含胰岛素0.1～10%,表面活性剂0.1～20%,pH 值为4.7～9.0。其制法:取猪胰岛素40mg,
The commonly used clinical insulin preparations are made injections. In recent years, foreign reports of new formulations of insulin reported more, in addition to the source of insulin research has some progress, described below. 1. Oral mucosal absorption preparations Oral absorption of the diaphragm membrane preparations, including oral buccal tablets, sublingual tablets, such as blowing loose. For example, buccal tablets of the system: Take gelatin 2.5g water appropriate amount of expansion, add lemon yellow (pigment) 0.3g, 0.25g sorbitol and insulin solution (4000 units) 50ml fully mixed, the mixture sieved vacuum drying at low temperature, Plus tablet accessories magnesium stearate 2g, talc 3g, Aerosil 0.07g total suppression 1000. 2.Drop nasal solution West Germany and Japan patent introduction nasal insulin solution containing insulin 0.1 to 10%, surfactant 0.1 to 20%, pH value of 4.7 to 9.0. The system of law: Take pig insulin 40mg,