目的：观察异丙嗪对家兔内毒素性发热及血清超氧化物歧化酶（ＳＯＤ）和脂质过氧化物丙二醛（ＭＤＡ）含量的影响。方法：复制家兔内毒素性发热模型，用黄嘌呤氧化酶法测定血清ＳＯＤ的活性，用改良巴比妥酸微量法测定血清ＭＤＡ的含量。结果：异丙嗪不仅完全抑制内毒素性发热，而且降低正常体温，该剂量的内毒素引起发热时，血清ＳＯＤ活性和ＭＤＡ含量未见明显改变，而静脉注射异丙嗪（２５ｍｇ／ｋｇ）却引起血清ＳＯＤ活性降低（Ｐ＜００５）和ＭＤＡ含量明显升高（Ｐ＜００５）。结论：在本实验条件下，内毒素性发热时血清自由基水平未见明显改变，而该剂量的异丙嗪有显著抑制内毒素性发热的作用并影响血清ＳＯＤ和ＭＤＡ的产生和代谢 Objective: To observe the effects of promethazine on endotoxin-induced fever and the levels of serum superoxide dismutase (SOD) and lipid peroxidation malondialdehyde (MDA) in rabbits. Methods: Rabbit model of endotoxin fever was replicated, the serum SOD activity was measured by xanthine oxidase method, and the content of serum MDA was measured by modified barbituric acid microdialysis method. Results: Promethazine not only completely inhibited endotoxin fever, but also decreased normal body temperature. When the dose of endotoxin caused fever, there was no significant change in serum SOD activity and MDA content. However, intravenous injection of promethazine (25 mg / kg) Serum SOD activity was decreased (P <005) and MDA content was significantly increased (P <005). Conclusion: Under the experimental conditions, there is no significant change of serum free radical level during endotoxin fever, while promethazine at this dose can significantly inhibit endotoxin-induced fever and affect the production and metabolism of serum SOD and MDA