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目的:考察临床常用表柔比星、长春新碱和依托泊苷(EPOCH)方案中药物混合配制的配伍稳定性。方法:选择临床常用3种药物剂量范围,混合配制低、中、高3种浓度注射液,考察不同浓度注射液室温放置24 h的配伍稳定性。结果:经过24 h室温未避光条件放置后,各组混合配制溶液性状未发生肉眼可见改变,分别使用液相色谱和液质联用方法进行检测,含量均在90%以上。结论:EPOCH混合配制方案在室温未避光条件下放置24 h稳定,配伍稳定,但仍需注意配制环节的风险和质量控制。
OBJECTIVE: To investigate the stability of the compatibility of the drugs commonly used in clinical epirubicin, vincristine and etoposide (EPOCH) regimen. Methods: The dosage range of three kinds of drugs commonly used in clinic was selected, and three kinds of low, medium and high concentrations of injection were mixed to investigate the compatibility stability of different concentrations of injection at room temperature for 24 hours. Results: After 24 h of room temperature without light exposure, the solution properties of the mixed solutions did not change macroscopically. The contents of the solutions were both over 90% by liquid chromatography and LC / MS. Conclusion: The EPOCH compound preparation scheme is stable for 24 h at room temperature under the condition of no light, but it still needs to pay attention to the risk and quality control of the preparation process.