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为探讨老年肺癌患者外周血淋巴细胞中ICAM 1的表达及化疗对其的影响 ,应用流式细胞术检测了 5 2例老年肺癌患者化疗前后外周血淋巴细胞中ICAM 1的含量 ,与 32例健康老人及 35例肺部良性疾患进行对比研究。结果发现 ,老年肺癌外周血ICAM 1的表达明显高于正常老人及肺部良性疾患 ;Ⅲ、Ⅳ期和Ⅰ、Ⅱ期肺癌患者之间ICAM 1的表达存在显著差异 ;且化疗后外周血中ICAM 1的表达水平明显低于化疗前。表明外周血ICAM 1表达的变化对判断老年肺癌患者疗效和预后有一定意义
To investigate the expression of ICAM-1 in peripheral blood lymphocytes of elderly patients with lung cancer and its effect on chemotherapy, the levels of ICAM-1 in peripheral blood lymphocytes of 52 elderly patients with lung cancer before and after chemotherapy were detected by flow cytometry, The elderly and 35 cases of benign pulmonary diseases were compared. The results showed that the expression of ICAM-1 in peripheral blood of elderly patients with lung cancer was significantly higher than that of normal elderly patients and benign lung diseases. There was significant difference in the expression of ICAM-1 between patients with stage III and IV lung cancer and those with stage I and II lung cancer. 1 expression was significantly lower than before chemotherapy. It is indicated that the change of ICAM-1 expression in peripheral blood is of certain significance in judging the curative effect and prognosis of elderly patients with lung cancer