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目的分析综合抗菌药物管理策略对住院患者抗菌药物消耗量及对非发酵菌耐药的影响。方法回顾性分析2010年-2013年某所综合性医院实施抗菌药物管理程序,对住院患者抗菌药物使用强度和鲍曼不动杆菌及铜绿假单胞菌的耐药率的影响。结果实施综合抗菌药物管理策略后,住院患者总抗菌药物、3代及4代头孢菌素、3代头孢菌素加酶抑制剂、氟喹诺酮的使用强度出现显著性下降,铜绿假单胞菌对头孢他啶的耐药率呈现下降趋势,鲍曼不动杆菌的耐药率无显著变化。结论严格执行综合抗菌药物管理措施可以有效降低住院患者抗菌药物使用强度,可能对铜绿假单胞菌的耐药状况产生有益的影响。
Objective To analyze the effect of integrated antimicrobial management strategies on the consumption of antimicrobial agents and the resistance to non-fermentative bacteria in hospitalized patients. Methods A retrospective analysis was conducted on the effect of antibacterials management procedures in a general hospital from 2010 to 2013 on the use of antibacterials in hospital and the drug resistance rate of Acinetobacter baumannii and Pseudomonas aeruginosa. Results After the implementation of the comprehensive antimicrobial management strategy, the use intensity of total antibiotics, 3rd and 4th generation cephalosporins, 3rd generation cephalosporin plus enzyme inhibitors and fluoroquinolone in hospitalized patients decreased significantly. Pseudomonas aeruginosa pairs The resistance rate of ceftazidime showed a downward trend, Acinetobacter baumannii no significant change in drug resistance. Conclusion Strict implementation of integrated antimicrobials management measures can effectively reduce the use of antimicrobial agents in hospitalized patients may have a beneficial impact on the drug resistance of Pseudomonas aeruginosa.