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目的:探讨应用肺表面活性物质(PS)治疗新生儿呼吸窘迫综合征(NRDS)的效果及治疗前后一氧化氮(NO)浓度的变化。方法:将2006年8月～2009年6月确诊为NRDS的患儿随机分为两组,一组使用鼻塞持续气道正压通气联合肺表面活性物质(简称NCPAP+PS组)、另一组为常规机械通气联合肺表面活性物质(简称CMV+PS组),比较两组疗效、肺部合并症及住院费用,观察NO浓度变化。结果:两组在治疗成功率、用机时间上差异无统计学意义;在氧疗时间及住院费用上NCPAP+PS组明显低于CMV+PS组,两者有统计学差异(P<0.01);NCPAP+PS组肺部感染发生数明显低于CMV+PS组(P<0.05);血清NO浓度升高。结论:①NCPAP+PS疗效与应用CMV+PS相似,能减少肺部感染等并发症的发生率,减少了氧疗时间、住院时间及住院费用;②PS可通过增加内源性NO治疗NRDS。
Objective: To investigate the effect of pulmonary surfactant (PS) on neonatal respiratory distress syndrome (NRDS) and the changes of nitric oxide (NO) before and after treatment. Methods: The children diagnosed as NRDS from August 2006 to June 2009 were randomly divided into two groups. One group received nasal continuous positive airway pressure ventilation combined with pulmonary surfactant (NCPAP + PS group) and the other group Conventional mechanical ventilation combined with pulmonary surfactant (abbreviated CMV + PS group), the two groups were compared efficacy, pulmonary complications and hospitalization costs, NO concentration was observed. Results: There was no significant difference between the two groups in the success rate of treatment and the time of using the machine. There was a significant difference between the two groups in NCPAP + PS group and oxygen therapy time and hospitalization cost (P <0.01) The incidence of pulmonary infection in NCPAP + PS group was significantly lower than that in CMV + PS group (P <0.05). The serum NO concentration increased. Conclusion: ① The effect of NCPAP + PS is similar to that of CMV + PS, which can reduce the incidence of complications such as lung infection and reduce the oxygen therapy time, hospitalization time and hospitalization cost; ②PS can treat NRDS by increasing endogenous NO.