抗癫痫药物间或抗癫痫药物与其他药物、化学物之间可发生各种相互作用。此种相互作用通过影响抗癫痫药物的吸收,血桨旦白结合,生物转化速率和清除排泄等过程,从而使抗癫痫药物的血浓度升高或下降。在治疗癫痫患者时,了解这种相互作用是很重要的。至今大部分报导涉及苯妥因钠(DPH)。已知许多药物可引起DPH血浓度升高,其机理通常认为由于DPH体内代谢受到抑制,在血浆中半衰期延长所致。 Antiepileptic drugs or antiepileptic drugs and other drugs, chemicals can occur between the various interactions. Such interactions increase or decrease the blood levels of antiepileptic drugs by influencing the absorption of antiepileptic drugs, blood plasma protein binding, rate of biotransformation and elimination of excretion. In the treatment of epilepsy patients, to understand this interaction is very important. Most reports so far have been on phenytoin sodium (DPH). Many drugs are known to cause elevated blood levels of DPH, a mechanism commonly believed to be due to prolonged half-life in plasma due to inhibition of DPH metabolism in vivo.