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目前有10％-15％的育龄夫妇受不孕症的困扰,其中病因在男方的约占50％。导致男性不育的因素大多与精子数目、形态及运动功能异常有关,其中精子发生过程的停滞或障碍也是引起男性不育的一个重要病因。所谓精子发生是指在精上皮的干细胞发育到成熟精子的一系列变化过程,其中任何一个环节异常均可导致精子生成障碍。生精障碍约占男性不育的10％,除输精管梗阻、腮腺炎病毒感染等明确病因外,相当一部分患者找不出发病原因,因此有关精子生成障碍的遗传学因素研究日益受到重视。随着分子遗传学技术的不断发展,从分子水平来研究精子发生障碍的机制,对男性不育症的诊断、治疗及预后判断具有非常重要的意义。
Currently, 10% -15% of couples of childbearing age suffer infertility, of which the cause is about 50% of the man. Most of the factors leading to male infertility and the number of sperm, morphology and motor function abnormalities, including spermatogenesis or stagnation of the process is also caused by male infertility is an important cause. The so-called spermatogenesis refers to a series of changes in the process of the development of sperm stem cells to mature sperm, any one of which can lead to abnormal sperm production obstacles. Spermatogenic disorders account for about 10% of male infertility, in addition to the clear causes of vas deferens obstruction, mumps virus infection, a considerable number of patients can not find the cause of the disease, so genetic factors related to spermatogenesis obstacles have received increasing attention. With the continuous development of molecular genetics, molecular mechanism of spermatogenesis is very important for the diagnosis, treatment and prognosis of male infertility.