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目的研究超声引导下穿刺活检组织中Survivin表达对肝癌预后判断的价值。方方法法36例经超声引导下穿刺所得的肝癌组织经免疫组化方法检测Survivin蛋白表达水平,并与临床病理学参数做统计学分析。结果肝穿组Survivin阳性表达率为63.9%(23/36),明显高于癌旁组织(25.0%,2/8),P<0.05,且与组织分化程度、有无癌栓密切相关(P均<0.05)。结论超声引导下肝肿物穿刺活检并检测肿瘤组织中Survivin蛋白的表达水平对肝癌预后判断具有一定的价值。
Objective To investigate the value of Survivin expression in biopsy tissue under ultrasound guidance for the prognosis of hepatocellular carcinoma. Methods Thirty - six cases of liver cancer tissue obtained by ultrasound guided puncture were detected by immunohistochemistry Survivin protein expression levels and clinical pathological parameters were analyzed. Results The positive rate of Survivin expression in hepatic tissue was 63.9% (23/36), which was significantly higher than that in paracancerous tissues (25.0%, 2/8), P <0.05 and closely related to the degree of tissue differentiation and the presence or absence of tumor thrombus All <0.05). Conclusion Ultrasound-guided biopsy of liver tumor and detection of the expression of Survivin protein in tumor tissue have a certain value for the prognosis of liver cancer.