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目的 评价培高利特对帕金森病的治疗效果并探讨药物剂量。方法 对 2 5例帕金森病病人使用培高利特治疗 ,在治疗前后进行多项运动障碍评分 ,并观察运动波动的变化。结果 改良 Hoehe- Yahr分级、Webster评分、NUDS评分 ,用药前后比较有显著性差异 (P<0 .0 2、P<0 .0 5、P<0 .0 5 ) ;而 Webster评分中震颤、僵直与坐起、手部动作过缓及步态均有显著性差异 (P<0 .0 0 1、P<0 .0 1、P<0 .0 2、P<0 .0 5 )。结论 培高利特对治疗帕金森病有显著疗效 ,并能改善运动波动
Objective To evaluate the therapeutic effect of pergolide on Parkinson’s disease and to explore the dose of the drug. Methods Twenty-five patients with Parkinson’s disease were treated with pergolide. The scores of dyskinesia were measured before and after treatment, and the changes of movement were observed. Results The modified Hoehe-Yahr classification, Webster score and NUDS score showed significant differences before and after treatment (P <0. 02, P <0 05, P <0 05) There was significant difference between sitting and hand movements and gait (P <0.01, P <0.01, P <0. 02, P <0.05). Conclusion Pergolide treatment of Parkinson’s disease have a significant effect, and can improve motor fluctuations