目的观察丹参、多巴胺和多巴酚丁胺对早产儿中、重度硬肿症的疗效。方法治疗组 15 8例在综合治疗的基础上加用复方丹参2 ml,每日 2次静滴 ,多巴胺、等量多巴酚丁胺加入 10 %葡萄糖液中 ,以 5μg/(kg· min)的速度持续输液泵静注。对照组 90例在综合治疗的基础上加用东莨菪碱每日 2次静滴 (病情变化时酌情加量 )。观察两组硬肿消退时间和病死率。结果治疗组硬肿消退时间为 (4.2 3± 0 .19)天 ,病死率 9.49%。对照组硬肿消退时间为 (6.16± 0 .3 1)天 ,病死率 2 4.44% ,经统计学处理 ,两组硬肿消退天数有非常显著性差异 (P<0 .0 1) ,两组病死率有非常显著性差异 (P<0 .0 1)。结论丹参、多巴胺和多巴酚丁胺对治疗早产儿中、重度硬肿症有协同作用 ,能缩短病程 ,降低病死率 Objective To observe the effect of Salvia miltiorrhiza, dopamine and dobutamine on premature infants with severe sclerema. Methods A total of 15 8 cases in the treatment group were treated with compound Salvia Miltiorrhiza 2 ml twice daily with dopamine and equivalent dobutamine in 10% dextrose solution at 5 μg / (kg · min) The infusion rate infusion pump infusion. The control group of 90 patients on the basis of comprehensive treatment plus scopolamine 2 times a day intravenously (when the disease changes, as appropriate). Two groups of sclerosis regression and mortality were observed. Results In the treatment group, the regression time of scleroderma was (4.2 3 ± 0.19) days and the case fatality rate was 9.49%. In the control group, the regression time of scleroderma was (6.16 ± 0.31) days and the mortality rate was 2.44%. There was a significant difference between the two groups (P <0.01) There was a very significant difference in case fatality rate (P <0.01). Conclusion Danshen, dopamine and dobutamine for the treatment of premature children with severe sclerosis have synergistic effects, can shorten the course of the disease and reduce the mortality