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目的探讨消化性溃疡发病机理的形态学改变。方法选择同一地区经胃镜取材、病理组织学确诊的消化性溃疡（Ｐｕ）患者及正常人（Ｎｓ）作对照研究，应用电子计算机图像分析处理系统及透射电镜技术对胃溃疡（Ｇｕ）、十二指肠球部溃疡（Ｄｕ）及Ｎｓ胃粘膜壁细胞进行体视学分析及超微结构观察。结果三者间壁细胞平均剖面直径（Ｄ）、平均剖面积（Ｓａ）、平均体积（Ｖｖ）、体积密度（Ｖｖｔ）和数量密度（Ｎｖ）均无显著差异（Ｐ＞０．２）；电镜下Ｄｕ组壁细胞呈分泌活跃相，Ｇｕ及Ｎｓ组则无明显差异。结论Ｄｕ患者的高胃酸状态与壁细胞泌酸功能增强有关，并非过去一直所认为的壁细胞总体增加。而胃溃疡较正常人无明显变化。证实Ｄｕ与Ｇｕ在病因学及发病机理方面具有不同质的理论学术观点
Objective To investigate the morphological changes of the pathogenesis of peptic ulcer. Methods The patients with peptic ulcer (Pu) and normal people (Ns) diagnosed by gastroscopy and histopathology in the same area were selected as the control study. The gastric ulcer (Gu), twelve The histopathological analysis and ultrastructure of duodenal ulcer (Du) and gastric mucosal parietal cells of Ns were observed. Results There was no significant difference (P> 0.2) between the average cell diameter (D), average sectional area (Sa), average volume (Vv), bulk density (Vvt) and number density Du parietal cells were secreted active phase, Gu and Ns group no significant difference. Conclusions The high gastric acid status in patients with Du is associated with an increase in acid secretion in parietal cells rather than the overall increase in parietal cells previously thought. The gastric ulcer no significant change than normal. Confirmed Du and Gu etiology and pathogenesis have different qualitative theoretical academic point of view