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目的探讨表皮生长因子受体(EGFR)和Ki67在上皮性卵巢癌中的表达及临床意义。方法采用免疫组化SP法检测EGFR和Ki67在上皮性卵巢癌、卵巢良性肿瘤和正常卵巢组织的表达情况。结果 EGFR和Ki67在上皮性卵巢癌组织与正常卵巢和卵巢良性肿瘤组织阳性的表达率有统计学差异(P<0.05)。EGFR和Ki67表达在肿瘤的组织学分级、临床分期和有无淋巴结转移中具有统计学差异(P<0.05)。结论 EGFR和Ki67在上皮性卵巢癌的发生、发展过程中起着重要的作用。
Objective To investigate the expression and clinical significance of epidermal growth factor receptor (EGFR) and Ki67 in epithelial ovarian cancer. Methods Immunohistochemical SP method was used to detect the expression of EGFR and Ki67 in epithelial ovarian cancer, benign ovarian tumor and normal ovarian tissue. Results The positive rates of EGFR and Ki67 in epithelial ovarian cancer tissues were significantly higher than those in normal ovarian tissues and benign ovarian tumors (P <0.05). The expression of EGFR and Ki67 in the tumor histological grade, clinical stage and with or without lymph node metastasis was statistically significant (P <0.05). Conclusion EGFR and Ki67 play an important role in the occurrence and development of epithelial ovarian cancer.