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为探讨脑内胆碱能神经系统与大鼠的吗啡条件性位置偏爱行为的关系，作者用体重200～250g雄性SD大鼠建立吗啡条件性位置偏爱模型。模型动物随机分为4组：①侧脑室注射生理盐水组，②侧脑室注射东莨碱组，③腹腔注射生理盐水组，④腹腔注射东莨碱组．测试前30min，给第2组侧脑室注入20μg东莨碱，对照组给予等量生理盐水。结果前者的吗啡条件性位置偏爱效应减弱（P＜0．05）．腹腔注射0．5mg／kg东莨碱对吗啡条件性位置偏爱效应影响不著。结果提示，脑内胆碱能神经系统参与吗啡偏爱效应的形成，东莨碱可能通过阻断脑内胆碱能M受体抑制了吗啡条件性位置偏爱行为。
To explore the relationship between the cholinergic system in the brain and morphine conditioned place preference in rats, a morphine-conditioned place preference model was established in male SD rats weighing 200-250 g. The model animals were randomly divided into 4 groups: ① lateral ventricle injection of saline group, ② intraventricular injection of scopolamine group, ③ intraperitoneal injection of saline group, ④ intraperitoneal injection of scopolamine group. 30min before the test, to the second group of intraventricular injection of 20μg caustic alkali, the control group was given the same amount of saline. Results The former morphine conditioned place preference effect weakened (P <0.05). Intraperitoneal injection of 0.5mg / kg of capersine had no effect on the conditioned place preference effect of morphine. The results suggest that the cholinergic nervous system in the brain is involved in the morphine preference effect, and scopolamine may inhibit morphine-induced conditioned place preference by blocking the cholinergic M receptor in the brain.