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目的:观察银杏达莫注射液联合厄贝沙坦氢氯噻嗪片对早期糖尿病肾病患者氧化应激水平及炎性因子的影响。方法:将104例早期糖尿病肾病患者随机分为2组各52例。2组均给予糖尿病常规治疗方法,对照组给予厄贝沙坦氢氯噻嗪片治疗,治疗组在对照组基础上给予银杏达莫注射液,连续治疗观察4周。观察2组治疗前后晚期氧化蛋白产物(AOPP)、超氧化物歧化酶(SOD)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平的变化。结果:治疗后,2组血清AOPP、SOD、IL-6、TNF-α水平均较治疗前改善(P<0.05),治疗组4项指标值的改善均优于对照组(P<0.05)。结论:银杏达莫注射液联合厄贝沙坦氢氯噻嗪片治疗早期糖尿病肾病有良好疗效,可能与两者联合应用可减轻氧化应激反应及抑制炎性因子产生相关。
Objective: To observe the effects of gingko Damo injection combined with irbesartan hydrochlorothiazide tablets on oxidative stress and inflammatory factors in patients with early diabetic nephropathy. Methods: 104 patients with early diabetic nephropathy were randomly divided into two groups of 52 cases. Both groups were given routine treatment of diabetes mellitus, the control group was treated with irbesartan hydrochlorothiazide tablets, the treatment group on the basis of the control group was given gingkangdamo injection, continuous treatment for 4 weeks. The levels of AOPP, SOD, IL-6 and TNF-α in the two groups before and after treatment were observed. Results: After treatment, the levels of serum AOPP, SOD, IL-6 and TNF-α in the two groups were improved compared with before treatment (P <0.05). The improvement of the four indexes in the treatment group was better than that in the control group (P <0.05). Conclusion: The combination of gingko Damo injection with irbesartan hydrochlorothiazide tablets in the treatment of early diabetic nephropathy has a good curative effect, which may be associated with the combination of the two to reduce the oxidative stress response and inhibit the production of inflammatory cytokines.