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番石榴酸(Piscidic acid)8是从Piscida crgthrina中分离得到的一种水溶性化合物,1948年W.Bridge等证明其结构为对羟基苄基酒石酸,1971年T.Yoshihara等确定其绝对构型为(2R,3S),1981年发现它具有明显的药理作用,该化合物的合成至今尚未见有成功的报道.我们以(+)-(2R,3R)-酒石酸为原料,按常法捌成二甲酯,再以
Piscidic acid 8 is a water-soluble compound isolated from Piscida crgthrina. In 1948, W. Bridge et al. Showed that its structure was p-hydroxybenzyl tartaric acid. In 1971, T. Yoshihara et al. Determined that the absolute configuration was (2R, 3S), it was found to have obvious pharmacological action in 1981.However, the synthesis of this compound has not been successfully reported until now.We take (+) - (2R, 3R) -tartaric acid as raw material, Methyl ester, and then