常用的外源性化合物多达6至7万种,均可通过各种途径进入体内损害机体,危害人类健康。现用的国际标准中,健康安全体外评价载体仍采用微生物、动物及人类永生化细胞、肿瘤细胞或原代培养细胞,但微生物和动物不能完全反映人类的生物学特征,肿瘤细胞不是正常健康的细胞,而原代培养细胞非单一来源细胞,无法进行标准化,因此,急需建立新的生物安全性评价的体外模型。 Commonly used exogenous compounds as many as 6 to 70,000 species, can enter the body through a variety of ways to damage the body, endangering human health. In the currently used international standards, the health and safety evaluation vector still adopts microorganisms, animal and human immortalized cells, tumor cells or primary cultured cells. However, the microorganisms and animals can not fully reflect human biological characteristics, and the tumor cells are not normally healthy Cells, while primary cultured cells are not single source cells and can not be normalized. Therefore, it is urgent to establish a new biosafety evaluation in vitro model.