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Pelger-Huet异常是一种以核的不完全分节和核染色质的异常凝结为特征的粒细胞显性遗传性疾病。各种疾病都可合并获得性或假性Pelger-Huet异常。它经常出现于骨髓增殖性疾病及白血病前期,因而被视为异常骨髓细胞株的标记。在无法分类的急性白血病,这种异常强烈地提示粒细胞白血病的诊断。通常中性细粒胞及嗜酸性粒细胞具有减数的分节和粗糙染色质。
Pelger-Huet Abnormalities is a dominant inherited granulocyte disease characterized by incomplete segregation of the nucleus and aberrant condensation of nuclear chromatin. Various diseases can be combined with acquired or pseudo Pelger-Huet abnormalities. It is often present in myeloproliferative disorders and pre-leukemia and is therefore considered a marker of abnormal bone marrow cell lines. In unclassifiable acute leukemias, this abnormality strongly suggests the diagnosis of myeloid leukemia. Normally, neutrophils and eosinophils have meiotic sections and rough chromatin.