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目的 :通过对 AL D的 MR图像上病变分布和信号特点进行分析 ,提高 MR对 AL D诊断的准确性。方法 :本组收集我院 1993～ 1999年间经生化和临床证实的 AL D共 18例 ,所有病例均在我院行 MR检查。结果 :18例病人均表现为对称性双侧脑室三角区白质病变 ,呈 T1 WI低信号 ,T2 WI高信号 ,其中 2例 (11% )仅累及枕叶 ,9例 (5 0 % )累及顶枕叶 ,7例 (39% )累及顶枕颞叶。18例 (10 0 % )累及胼胝体压部和脑干皮质脊髓束 ,16例 (89% )累及丘脑后外部。 4例增强扫描表现为病灶周边环状强化 ,脑干病灶亦强化。结论 :AL D典型表现为双侧对称性侧脑室三角区白质病变并累及脑干和胼胝体压部。 MR为一种无创性的敏感方法 ,能准确反映 AL D病变和病程
OBJECTIVE: To improve the diagnostic accuracy of MR for ALD by analyzing the lesion distribution and signal characteristics of MR images of ALD. Methods: We collected 18 cases of ALD biochemically and clinically confirmed in our hospital from 1993 to 1999. All patients underwent MR examination in our hospital. Results: Eighteen patients showed symmetric bilateral ventricular white matter lesions with low signal of T1WI and high signal of T2WI, of which 2 cases (11%) only involved the occipital lobe and 9 cases (50%) involved the top Occipital lobe, 7 cases (39%) involving the top occipital temporal lobe. Eighteen patients (100%) involved the corpus callosum and the brainstem cortical spinal cord bundle, and 16 (89%) involved the posterior thalamic outside. In 4 cases, the enhanced scan showed annular enhancement around the lesion and the brain stem lesions were also strengthened. CONCLUSION: The typical manifestation of ALD is bilateral symmetrical lateral ventricles of the white matter lesions involving the brainstem and the corpus callosum. MR is a noninvasive and sensitive method that accurately reflects the AL D disease and course of disease