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目的：通过对比有无侧枝循环的冠心病患者冠脉成形术(PTCA)前后白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)水平的变化，探讨PTCA引起早期炎性反应的机制。方法：参照Leaman冠脉积分系统，对PTCA球囊阻断引起的缺血强度进行量化。计算正常对照组与冠心病组PTCA手术前后的IL-6、TNF-α水平变化，并进行相关性分析。结果：缺血性刺激前IL-6和TNF-α分别为(9.592±1.847)pg/ml和(26.959±1.967)pg/ml，在缺血刺激后4h分别为(27.423±1.882)pg/ml和(78.542±1.573)pg/ml，呈显著性差异。结论：IL-6、TNF-α是反映PTCA术后早期炎性反应的敏感指标，缺血积分可作为反映PTCA术中缺血/再灌注损伤程度的量化指标，侧支循环可减轻PTCA术后早期炎症反应。“,”Objective:Inflamatory responses play an important role in the post-percutaneous transluminal coronary angioplasty(PTCA) restenosis and have been demonstrated occuring immediately after PTCA. I nterleukin-6(IL-6) and the tumor necrosis factor-α(TNF-α) are the main inflamatory cytokines. We try to compare the changes of Interleukin-6(IL-6) and the tumor necrosis factor-α(TNF-α) after PTCA in the patients with and without collateral circulation to probe into the pathogenesis of early inflammatory response. Methods:The extent of myocardial ischemia induced by balloon inflation was quantified by a scoring system referring to the Leaman coronary score. The IL-6,TNF-α levels of coronary heart disease group and control group before and after PTCA are calculated. Results: The concentrations of IL-6 and TNF-a were (9. 592+ 1. 847)pg/ml and (26. 959+1. 967)pg/ml;and were significantly increased(27. 423 + 1. 882)pg/ml and(78. 542 + 1. 573)pg/ml 4 hours after PTCA. Conclusion:IL-6 and TNF-α are sensitive resembles of the early inflamatory response after PTCA. Ischemia scores reflected the extent of ischemia refusion injury during PTCA. Collateral circulation decreased the early inflamatory response after PTCA.