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随着慢性乙肝抗病毒治疗观念的普及,越来越多的慢性乙肝患者开始了抗病毒治疗。如何做到长期、规范治疗,是抗病毒治疗成功与否的关键。新版《中国慢乙肝防治指南》明确指出:有临床研究显示,因对某一核苷(酸)类发生耐药而先后改用其他苷(酸)类药物治疗,可筛选出对多种苷(酸)类耐药的变异株。因此,应避免单药序贯治疗。序贯治疗即我们通常讲的换药。在乙肝抗病毒治疗过程中,随意换药不仅不能提高疗效,反而会导致耐药。因此,乙肝患者一旦开始抗病毒治疗,必须按照流程规范进行,千万不要随便停药或
With the popularization of the concept of chronic hepatitis B antiviral treatment, more and more chronic hepatitis B patients begin antiviral therapy. How to achieve long-term, standardized treatment is the key to the success of antiviral treatment. The new version of “Guideline for Prevention and Treatment of Chronic Hepatitis B in China” states clearly that: Clinical studies have shown that due to resistance to certain nucleosides (acids), they have been switched to other glycosides (acids) Acid) resistant variant strains. Therefore, single-agent sequential therapy should be avoided. Sequential treatment that we usually talk dressing. Hepatitis B antiviral therapy in the process of dressing change not only can not improve the efficacy, but will lead to resistance. Therefore, hepatitis B patients once started antiviral therapy, must follow the process specifications, do not just stop the drug or