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目的了解α1-抗糜蛋白酶基因exonⅢPro229→Ala突变在广东籍儿童中发生的情况。方法用PCR-RFLP方法检测100例广东籍正常儿童和52例支气管哮喘患儿α1-抗糜蛋白酶基因exonⅢPro229→Ala突变情况。结果所有样本均未检出α1-抗糜蛋白酶基因exonⅢPro229→Ala突变。结论从目前调查的例数,广东籍支气管哮喘患儿中尚未发现α1-抗糜蛋白酶基因exonⅢPro229→Ala突变。
Objective To understand the occurrence of α1-chymotrypsin gene exonⅢPro229 → Ala mutation in Guangdong children. Methods The mutation of exonⅢPro229 → Ala of α1-chymotrypsin gene in 100 children with normal Guangdong and 52 children with bronchial asthma was detected by PCR-RFLP. Results No α1-antichymotrypsin gene exonⅢPro229 → Ala mutation was detected in all the samples. Conclusion From the current number of cases investigated, there is no exonⅢPro229 → Ala mutation of α1-chymotrypsin gene in Guangdong children with bronchial asthma.