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目的:研究醌氧化还原酶(NQO1)基因多态性和急性髓系白血病易感性的关系。方法:用1:1配对病例-对照方法,PCR-LDR方法,对78例急性髓系白血病患者(AML)和100例对照人群进行NQO1基因突变分析。结果:AML病例组NQO1基因T等位基因频率(43%)和TC/TT基因型频率(63%)均高于对照组(28%和43%)。携带TC/TT基因型的个体发生AML的相对风险度为其野生型(CC)的1.67倍(95%CI=1.212～2.727)。结论:NQO1基因多态性与AML遗传易感性相关,等位基因C对AML易感性有保护作用。
Objective: To investigate the relationship between the polymorphism of quinone oxidoreductase (NQO1) gene and susceptibility to acute myeloid leukemia. Methods: The NQO1 gene mutation was analyzed in 78 patients with acute myeloid leukemia (AML) and 100 control subjects by 1: 1 matched case-control method and PCR-LDR method. Results: The T allele frequency (43%) and TC / TT genotype frequency (63%) of NQO1 gene in AML cases were higher than that in control group (28% and 43%). The relative risk of developing AML in individuals with the TC / TT genotype was 1.67 times (95% CI = 1.212-2.727) of their wild type (CC). Conclusion: NQO1 gene polymorphism is associated with genetic susceptibility to AML and allele C is protective against AML susceptibility.