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鉴于年幼或在化疗中伴有恶心、呕吐副作用的高尿酸血症患者宜口服别嘌醇片,本文研究了口服别嘌醇片和直肠给药后,别嘌醇栓剂的生物利用度。同时,在体外以动态渗析法研究别嘌醇与PEG间的关系。实验结果表明,健康受试者(5人)口服别嘌醇片的血浆峰药浓度在5.2±0.65小时时达到1.5±0.25μg/ml。给予用可可豆油制成的别嘌醇栓剂后,于血浆中未能测得别嘌醇。氧化产物的峰浓度在13±11小时时为0.34±0.14μg/ml。相对于片剂,可可豆油栓的别嘌
In view of young or in chemotherapy with nausea, vomiting, side effects of hyperuricemia patients should oral allopurine tablets, this paper studies allopurinol tablets and rectal administration, allopurinol suppository bioavailability. Meanwhile, the relationship between allopurinol and PEG was studied in vitro by dynamic dialysis. The experimental results show that the plasma peak drug concentration of oral allopurinol tablets in healthy subjects (5 persons) reached 1.5 ± 0.25 μg / ml at 5.2 ± 0.65 hours. After given allopurinol suppository made with cocoa butter, allopurinol was not detected in plasma. The peak concentration of the oxidation product was 0.34 ± 0.14 μg / ml at 13 ± 11 hours. Relative to the tablet, cocoa butter allopiperazine