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目的:了解6年来文献报道中药品不良反应(ADR)病例的分布概况。方法:统计《药物流行病学杂志》2000～2005年的全年载文关键词索引中涉及 ADR 的病例报道,对其进行统计、分析。结果:ADR 的病例报道呈上升趋势。在报道的全部病例中,以过敏反应比例最高占42.97%,引起过敏反应的药物以抗感染药为主;过敏性休克构成比高达24.42%;涉及中成药的病例占22.18%。结论:对于药品不良反应,要加强监测及时上报,临床应提高警惕,多渠道接受新信息,以减少 ADR 的重复发生,确保用药安全。
OBJECTIVE: To understand the distribution of ADR cases reported in the literature over the past 6 years. Methods: The case reports of ADR in the index of Chinese published articles of the journal “Journal of Pharmaceutical Epidemiology” from 2000 to 2005 were statistically analyzed and statistically analyzed. Results: The number of reported cases of ADR is on the rise. Among all reported cases, the highest proportion of allergic reactions accounted for 42.97%. The anti-allergic drugs were mainly anti-infectives; the constituent ratio of anaphylactic shock was as high as 24.42%; and the cases involving proprietary Chinese medicines accounted for 22.18%. Conclusion: For the adverse reactions of drugs, it is necessary to strengthen the monitoring and timely reporting, and should be vigilant in clinical practice and receive new information in multiple channels so as to reduce the repetitive occurrence of ADR and ensure the safety of medication.