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[目的]探讨糖皮质激素在创伤致急性呼吸窘迫综合征患者救治中的临床效果。[方法]选取2007年1月～2011年6月于某院进行治疗的42例创伤致急性呼吸窘迫综合征患者为研究对象,将其随机分为对照组(常规治疗组)21例和观察组(加用糖皮质激素组)21例,后将两组患者的死亡率、机械通气时间、住院时间及治疗前后的氧合指数、尿量、APACHEⅡ评分、血清NO、ET-1、IL-1β、IL-6、CRP、TNF-α水平进行统计及比较。[结果]观察组的死亡率低于对照组,机械通气时间、住院时间均短于对照组,氧合指数高于对照组,尿量大于对照组,APACHEⅡ评分低于对照组,血清NO、ET-1、IL-1β、IL-6、CRP、TNF-α水平均低于对照组,P均﹤0.05,差异均有统计学意义。[结论]糖皮质激素在创伤致急性呼吸窘迫综合征患者救治中的临床效果好,可显著改善预后。
[Objective] To investigate the clinical effect of glucocorticoids in the treatment of acute respiratory distress syndrome patients with trauma. [Methods] Forty-two patients with acute respiratory distress syndrome who were treated in a hospital from January 2007 to June 2011 were selected as study subjects and randomly divided into control group (21 cases) and observation group (Plus glucocorticoid group) 21 cases. The mortality, mechanical ventilation time, hospital stay and oxygenation index, urine output, APACHEⅡscore, serum NO, ET-1, IL-1β , IL-6, CRP, TNF-α levels were statistically compared and compared. [Results] The mortality of the observation group was lower than that of the control group, the duration of mechanical ventilation and hospital stay were shorter than that of the control group, the oxygenation index was higher than that of the control group, the urine output was greater than that of the control group, APACHE II score was lower than that of the control group, 1, IL-1β, IL-6, CRP and TNF-α were significantly lower than those in the control group (all P <0.05), the differences were statistically significant. [Conclusion] The clinical effect of glucocorticoids in the treatment of patients with traumatic acute respiratory distress syndrome is good, which can significantly improve the prognosis.