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目的了解广东省中山市艾滋病病毒(HIV)感染者和艾滋病(AIDS)病人(简称HIV/AIDS病人)的配偶HIV抗体检测及随访HIV抗体阳转情况。方法从国家艾滋病综合防治信息系统中下载病例报告信息和随访信息,采用SPSS分析2010-2012年中山市新发现的已婚HIV/AIDS病人的配偶检测及随访情况,随访信息截止时间为2013年12月31日。结果 213例已婚HIV/AIDS病人被纳入分析,175例(82.2%)的配偶接受过HIV检测,其中41.1%(72/175)的配偶首次检出HIV抗体阳性。女性病例配偶的HIV抗体阳性率是男性病例配偶抗体阳性率的2.31倍[相对危险度(RR)=2.31,95%可信区间(CI):1.62~3.3]。文化程度越高,配偶HIV抗体阳性率越低(趋势χ2=5.73,P=0.02)。配偶接受HIV抗体检测的HIV/AIDS病人中,100例在确诊后2个月内进行了CD+4T淋巴细胞(简称CD4细胞)计数检测,其中47例<200个/μL,26例200~349个/μL;CD4细胞<350个/μL的配偶HIV抗体检测阳性率是CD4细胞≥350个/μL病例配偶的2.28倍(RR=2.28,95%CI:1.09~4.79)。配偶首次检测HIV抗体阴性的103例HIV/AIDS病人中,68例(66.0%)的配偶完成随访≥1次,合计随访81.8人年,其中1例出现阳转,阳转率为1.22/100人年(95%CI:0~3.6/100人年)。结论中山市发现已婚HIV/AIDS病人,配偶首次检测HIV阳性率高。今后工作应促进病例早发现,提高配偶HIV检测率和随访率。
Objective To understand the spouse HIV antibody detection and follow-up of HIV antibody positive cases among HIV-infected and AIDS patients (referred to as HIV / AIDS patients) in Zhongshan City, Guangdong Province. Methods The case reports and follow-up information were downloaded from the national AIDS integrated prevention and control information system. SPSS was used to analyze spouse detection and follow-up of newly discovered HIV / AIDS patients in Zhongshan City from 2010 to 2012. The deadline for follow-up information was 2013 On the 31st of the month. Results 213 married HIV / AIDS patients were included in the analysis, and 175 (82.2%) spouses were tested for HIV, of whom 41.1% (72/175) spouses were HIV positive for the first time. The positive rate of HIV antibody in female case spouses was 2.31 times of the positive rate of male spouse antibody [relative risk (RR) = 2.31, 95% confidence interval (CI): 1.62-3.3]. The higher the education level, the lower the HIV positive rate of spouse (trend χ2 = 5.73, P = 0.02). Of HIV / AIDS patients whose spouses were tested for HIV antibody, 100 patients were counted for CD + 4 T lymphocyte (CD4) count within 2 months after diagnosis, of which 47 were less than 200 / μL and 26 were 200-3 349 / ΜL; spouses with CD4 cells <350 cells / μL HIV antibody positive rate was 2.28 times (RR = 2.28, 95% CI: 1.09 to 4.79) for spouses of ≥350 cells / μL CD4 cells. Of the 103 HIV / AIDS-naive HIV-negative patients whose spouses were the first to be detected, 68 (66.0%) of the spouses were followed up for more than 1 times, with a total follow-up of 81.8 years, of which 1 was positive and the positive rate was 1.22 / 100 Year (95% CI: 0 ~ 3.6 / 100 person-years). Conclusion In Zhongshan City, married couples with HIV / AIDS were found to have the highest positive rate of HIV testing for the first time. Future work should promote the early detection of cases and improve HIV detection rate and follow-up rate of spouses.