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右美托咪定为高选择性α2受体激动剂,除具有剂量依赖性镇静、镇痛、抗焦虑和抑制交感神经兴奋性等作用,近年来大量研究证实其还具有抗炎作用.其可能抗炎机制有:(1)激活胆碱能抗炎通路;(2)抑制单核巨噬细胞和小胶质细胞炎性因子的表达;(3)抑制Toll样受体4-核因子κB途径.右美托嘧嘧啶的抗炎效应与脑保护、心保护、肾保护和肺保护等器官保护密切相关.但右美托咪定的具体抗炎机制和临床效应仍需进一步基础与临床试验加以验证.“,”Dexmedetomidine is a highly selective α2 adrenoreceptor agonist,besides its characteristics as sedation,analgesia,antianxiety,sympatholytic properties,its anti-inflammatory effect has been demonstrated recently,which relates to its organ-protective effects.Attenuation of inflammation by dexmedetomidine is associated with activation of a cholinergic anti-inflammatory pathway,supression of MCP-1 expression in primary astrocyte,and downregulation of the high mobility group box 1-toll-like receptor 4-nuclear factor kappaB signalling pathway.In general,the exact mechanisms of its anti-inflammatory effects are still unclear.Future studies will be necessary to clarify the mechanism responsible for its anti-inflammatory effects.