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目的:优选复方百部颗粒组方药味的配伍比例。方法:采用正交设计法,从多因素、多水平对复方百部颗粒3味药止咳有效部位进行最佳配伍比例的动物药效学研究,以咳嗽次数和咳嗽潜伏期及酚红排出量为考察指标,从中得出最佳配伍比例。结果:经实验得出最佳配伍比例为:百部24 g,桔梗12 g,紫菀12 g。结论:此复方配伍比例研究方法切实可行,为其临床应用提供一定的理论依据。
Objective: To optimize the compatibility ratio of herbal taste of compound Baibu granules. METHODS: The pharmacodynamics study of the best combination of cough, cough latency, and phenol red output was conducted using orthogonal design method from multiple factors and multiple levels on the effective anti-tussive part of compound Baibu granules. Indicators, from which to find the best proportion of compatibility. RESULTS: The optimum proportions obtained by experiments were as follows: 24 g of Bai, 12 g of Platycodon, and 12 g of Aster. Conclusion: This research method of compound proportion is practical and feasible, and it provides a certain theoretical basis for its clinical application.