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应用放射免疫分析法前瞻性检测176例发生急性肺损伤(ALI)高危因素的患者血清铁蛋白水平,随后56例发生了ALI。结果发现高危患者血清铁蛋白水平显著高于正常对照组(P<0.01),高危患者发展为ALI者又显著高于未发展为ALI者(P<0.01),女性以>280μg/L预测ALI灵敏度为80.9%,特异度86.8%,男性以>630μg/L预测ALI灵敏度为85.7%,特异度88.1%。结果表明血清铁蛋白水平可作为预测ALI发生的良好指标用于临床。
Radioraimmunoassay was used to prospectively detect serum ferritin levels in 176 patients at high risk of acute lung injury (ALI), followed by ALI in 56 patients. Serum ferritin levels in high-risk patients were significantly higher than those in normal controls (P <0.01), those in high-risk patients who developed ALI were significantly higher than those who did not develop ALI (P <0.01) L predicts ALI with a sensitivity of 80.9% and a specificity of 86.8%. Men with a sensitivity of> 630μg / L predict ALI with a sensitivity of 85.7% and a specificity of 88.1%. The results show that serum ferritin levels can be used as a good indicator of the occurrence of ALI for clinical use.