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氯乙醇（ＣＥ）与肝线粒体或微粒体共同温浴，引起线粒体、微粒体的脂质过氧化（ＬＰＯ）表现为两二醛（ＭＤＡ）升高，同时，还引起荧光偏振度（Ｐ）降低（膜脂流动性升高），与对照组比较具有显著性差别，且存在着剂量－反应关系及时间－反应关系。在本实验条件下，发现巯基供剂二硫苏糖醇（ＤＴＴ）、过氧化物歧化酶（ＳＯＤ）对膜脂流动性均无保护作用，说明在该模型的实验条件下，荧光偏振度（Ｐ）的降低可能与脂质过氧化无关，可能由于ＣＥ既具有脂溶性又具有水溶性，能进入膜脂的中间层，破坏疏水环境所致。
Chloroethanol (CE) incubated with liver mitochondria or microsomes resulted in increased lipid peroxidation (LPO) in mitochondria and microsomes as well as increased dialdehyde (MDA), as well as decreased fluorescence polarization (P) Membrane fluidity increased) compared with the control group had significant differences, and there is a dose-response relationship and time-response relationship. Under these experimental conditions, it was found that the dithiothreitol (DTT) and the superoxide dismutase (SOD) had no protective effect on the fluidity of the membrane lipid, indicating that under the experimental conditions of this model, the fluorescence polarization degree P) reduction may not be related to lipid peroxidation, probably because CE is both fat-soluble and water-soluble, can enter the membrane lipid intermediate layer, destroying the hydrophobic environment.