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目的观察高强度聚焦超声(HIFU)治疗裸鼠卵巢癌皮下移植瘤的病理变化。方法将12只接种人卵巢癌细胞株SKOV3的裸鼠,当肿瘤体积达1.0cm3左右时,采用HIFU照射治疗肿瘤的外侧约1/2。于治疗后即刻和治疗后2周分别观察病理变化。结果镜下见靶区内肿瘤组织完全凝固性坏死。结论HIFU能够有效治疗裸鼠卵巢癌皮下移植瘤,可望成为治疗卵巢癌有前途的新方法。
Objective To observe the pathological changes of subcutaneously transplanted ovarian cancer in nude mice by high intensity focused ultrasound (HIFU). Methods 12 nude mice inoculated with human ovarian cancer cell line SKOV3 were treated with HIFU irradiation for about 1/2 of the tumor when the tumor volume reached 1.0cm3. Pathological changes were observed immediately after treatment and 2 weeks after treatment. Results of the microscope to see the tumor area completely coagulation necrosis. Conclusion HIFU can effectively treat subcutaneous xenografts of ovarian cancer in nude mice and is expected to become a promising new method for the treatment of ovarian cancer.